Karthik Muthuraman was born to Muthuraman who was also a famous actor. He was born in Chennai, Tamil Nadu. He studied at New College, Chennai and got a Bachelors Degree (B.A). Karthik Muthuraman's onscreen title is Navarasa Nayagan

Karthik is a Tamil actor, son of veteran actor R. Muthuraman, and has acted in more than 100 films. He was first introduced by Bharathiraja in the film "Alaigal Oivathilai". He has acted in Tamil and Telugu films. He has received the Best New Face Award from the Tamil Nadu Government in 1980, the Kalaimamani Award and the Telugu Nandi Award for "Abhinandana".

He has received the Best New Face Award from the Tamil Nadu Government in 1980, the Kalaimamani Award and the Telugu Nandi Award for Abhinandana. He has received the best actor for three consecutive times by tamilnadu government. He is popular with the audience for sense of humour and was involved with several rib tickling scenes in most of his movies. His cameo in Mouna Ragam was very well received by the audience. During his later years, he formed a partnership with Goundamani in doing comedy scenes.